BOMB trial: First results of stereotactic radiotherapy to primary breast tumor in metastatic breast cancer patients.

ABSTRACT:

Aim

A prospective dose escalation trial was developed to evaluate the maximum tolerated dose of stereotactic body radiotherapy (SABRT) to primary breast cancer in stage IV disease. The aim of the present report was to describe safety and outcome of the first dose level cohort of patients.

Material and methods

Patients with histologically confirmed diagnosis of invasive breast carcinoma (biological immuno-histochemical profile: luminal and/or HER2 positive) and distant metastatic disease not progressing after 6 months of systemic therapy with a tumor CT or 5FDG-PET detectable were deemed eligible. The starting dose was 40 Gy in 5 fractions (level 1) because this dose proved to be safe in previous dose-escalation trial on adjuvant stereotactic body radiotherapy. The maximum do

SUBMITTER: Ippolito E 

PROVIDER: S-EPMC10064004 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature