No Strong Association between the Apolipoprotein E E4 Allele and Glaucoma: A Multicohort Study.

ABSTRACT:

Purpose

To elucidate a potential association between the apolipoprotein E (APOE) E4 allele and glaucoma prevalence in large cohorts.

Design

A cross-sectional analysis of baseline and prospectively collected cohort data.

Participants

UK Biobank (UKBB) participants of genetically determined European ancestry (n = 438 711). Replication analyses were performed using clinical and genotyping data collected from European participants recruited to the Canadian Longitudinal Study of Aging (CLSA; n = 18 199), the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG; n = 1970), and the Blue Mountains Eye Study (BMES; n = 2440).

Methods

Apolipoprotein E alleles and genotypes were determined, and their distributions were compared on the basis of glaucoma

SUBMITTER: Mullany S 

PROVIDER: S-EPMC10064233 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature