Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole.

ABSTRACT: Venetoclax requires a 75% dose reduction when coadministered with voriconazole. In a 10-year historical cohort of treatment with venetoclax, we did not observe a worse hematologic outcome in patients who received voriconazole prophylaxis versus those who did not. Subtherapeutic voriconazole levels and a triazole exposure history may contribute to breakthrough invasive fungal infection.

SUBMITTER: Hall VG 

PROVIDER: S-EPMC10064263 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature