Ontology highlight
ABSTRACT:
SUBMITTER: Estes Bright LM
PROVIDER: S-EPMC10064314 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Estes Bright Lori M LM Garren Mark Richard Stephen MRS Douglass Megan M Handa Hitesh H
ACS applied materials & interfaces 20230316 12
Biofilm formation on biomaterial interfaces and the development of antibiotic-resistant bacteria have decreased the effectiveness of traditional antibiotic treatment of infections. In this project, ampicillin, a commonly used antibiotic, was conjugated with <i>S</i>-nitroso-<i>N</i>-acetylpenicillamine (SNAP), an <i>S</i>-nitrosothiol compound (RSNO) used for controlled nitric oxide (NO) release. This novel multifunctional molecule is the first of its kind to provide combined antibiotic and NO t ...[more]