GLP-1 Receptor Agonists Induce Growth Hormone Secretion in Healthy Volunteers.

ABSTRACT:

Introduction

Growth hormone (GH) is an essential regulator of growth, body composition and fuel metabolism and, consequently, GH secretion is under the feedback control of numerous nutritional and endocrine mediators. Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to exert pleiotropic effects, including stimulation of the activity of the hypothalamic-pituitary-adrenal axis. As GLP-1RAs exert multiple metabolic effects, we hypothesised that they may also affect the secretion of GH and examined the effect of a short-acting and a long-acting GLP-1 RA on GH secretion.

Methods

This is a post hoc analysis of data from clinical trials. Two separate single-group open-label clinical trials were carried out in the ambulatory care setting with a duration of 1 and

SUBMITTER: Heinla K 

PROVIDER: S-EPMC10064408 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature