Impact of Type 2 Diabetes Duration on the Efficacy and Safety of Add-on Lixisenatide in Asian Individuals Receiving Basal Insulin: A Pooled Analysis.

ABSTRACT:

Introduction

This analysis investigated the efficacy and safety of add-on lixisenatide by disease duration in Asian people with type 2 diabetes inadequately controlled with basal insulin ± oral antidiabetic drugs.

Methods

Data for Asian participants in the GetGoal-Duo 1, GetGoal-L, and GetGoal-L-C studies were pooled and categorized by diabetes duration: < 10 years (group 1), 10 to < 15 years (group 2), and ≥ 15 years (group 3). Efficacy and safety of lixisenatide versus placebo were evaluated by subgroup. The potential influence of diabetes duration on efficacy was examined using multivariable regression analyses.

Results

A total of 555 participants were included (mean age 53.9 years, 52.4% male). No significant differences in treatment effect between the duration su

SUBMITTER: Yao J 

PROVIDER: S-EPMC10064411 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature