Low human beta-defensin-2 levels in the sputum of COPD patients are associated with the risk of exacerbations.

ABSTRACT:

Rationale

Chronic obstructive pulmonary disease (COPD) is a complicated chronic inflammatory disease. It is important to investigate the characteristics of acute exacerbation of COPD to develop new therapeutic strategies.

Objective

This study aimed to determine the relationship between the human beta-defensin-2 (hBD-2) levels and aggravation of COPD.

Methods

We detected the sputum hBD-2 level of 254 patients from Guangzhou, China, for 2 years. The study participants were categorized into the COPD group (n = 203, GOLD 0-4) and the control group (n = 51, 40-79 years old). At baseline, 12th month, and 24th month, we detected the sputum hBD-2 level and levels of cytokines, such as CXCL10, CXCL11, and IFN.

Results

At baseline, there were no significant differences i

SUBMITTER: Feng S 

PROVIDER: S-EPMC10064533 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature