Treatment of COVID-19 pneumonia with low-dose radiotherapy plus standard of care versus standard of care alone in frail patients : The SEOR-GICOR IPACOVID comparative cohort trial.

ABSTRACT:

Purpose

To assess the efficacy of lung low-dose radiotherapy (LD-RT) in the treatment of patients with COVID-19 pneumonia.

Materials and methods

Ambispective study with two cohorts to compare treatment with standard of care (SoC) plus a single dose of 0.5 Gy to the whole thorax (experimental prospective cohort) with SoC alone (control retrospective cohort) for patients with COVID-19 pneumonia not candidates for admission to the intensive care unit (ICU) for mechanical ventilation.

Results

Fifty patients treated with LD-RT were compared with 50 matched controls. Mean age was 85 years in both groups. An increase in arterial oxygen partial pressure (PaO₂)/fraction of inspired oxygen (PAFI) in the experimental LD-RT-treated group compared to the control group c

SUBMITTER: Arenas M 

PROVIDER: S-EPMC10064634 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature