Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease.

ABSTRACT:

Background

Crohn's disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on the presence of microbial triggers. Increased abundance of unknown Clostridiales and the microscopic detection of filamentous structures close to the epithelium of Tnf ^ΔARE mice, a mouse model of CD-like ileitis pointed towards segmented filamentous bacteria (SFB), a commensal mucosal adherent bacterium involved in ileal inflammation.

Results

We show that the abundance of SFB strongly correlates with the severity of CD-like ileal inflammation in two mouse models of ileal inflammation, including Tnf ^ΔARE and SAMP/Yit mice. SFB mono-colonization of germ-free Tnf ^ΔARE mice confirmed the causal link and re

SUBMITTER: Metwaly A 

PROVIDER: S-EPMC10064692 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature