Biokinetics of subacutely co-inhaled same size gold and silver nanoparticles.

ABSTRACT:

Background

Toxicokinetics of nanomaterials, including studies on the absorption, distribution, metabolism, and elimination of nanomaterials, are essential in assessing their potential health effects. The fate of nanomaterials after inhalation exposure to multiple nanomaterials is not clearly understood.

Methods

Male Sprague-Dawley rats were exposed to similar sizes of silver nanoparticles (AgNPs, 10.86 nm) and gold nanoparticles (AuNPs, 10.82 nm) for 28 days (6-h/day, 5-days/week for four weeks) either with separate NP inhalation exposures or with combined co-exposure in a nose-only inhalation system. Mass concentrations sampled from the breathing zone were AuNP 19.34 ± 2.55 μg/m³ and AgNP 17.38 ± 1.88 μg/m³ for separate exposure and AuNP 8.20 μg/m

SUBMITTER: Lee P 

PROVIDER: S-EPMC10064767 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature