Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway.

ABSTRACT:

Context

Endometrial cancer is a common gynecologic malignancy. Vitexin is an active flavonoid compound with an antitumor function.

Objective

This study elucidated the role of vitexin in endometrial cancer development and clarified the potential mechanism.

Materials and methods

The toxicity of vitexin (0-80 μM) treatment for 24 h on HEC-1B and Ishikawa cells was tested utilizing the CCK-8 assay. Endometrial cancer cells were divided into vitexin 0, 5, 10, and 20 μM groups. Cell proliferation, angiogenesis and stemness in vitro after treatment with vitexin (0, 5, 10, 20 μM) for 24 h were evaluated using the EdU staining assay, tube formation assay and sphere formation assay, respectively. Twelve BALB/c mice were grouped into control and vitexin (80 mg/kg) groups

SUBMITTER: Liang C 

PROVIDER: S-EPMC10064825 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature