Hippocampal subfield morphology in regular hemodialysis patients.

ABSTRACT:

Background

Hippocampal alterations have been implicated in the pathophysiology of cognitive impairment in hemodialysis patients. The hippocampus consists of several distinct subfields, and the molecular mechanisms underlying cognition might be associated with specific hippocampal subfield volume changes. However, this has not yet been investigated in hemodialysis patients. This study aimed to explore volumetric abnormalities in hippocampal subfields in regular hemodialysis patients.

Methods

High-resolution T1-weighted structural images were collected in 61 subjects including 36 hemodialysis patients and 25 healthy controls. A state-of-the-art hippocampal segmentation approach was adopted to segment the hippocampal subfields. Group differences in hippocampal subfield volumes

SUBMITTER: Chen HJ 

PROVIDER: S-EPMC10064839 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature