Evaluation of the self-administration potential of high-density microarray patches to human skin: A preliminary study.

ABSTRACT: The high-density microneedle array patch (HD-MAP) is a novel vaccine delivery system with potential for self-administered vaccination. In this study, Vaxxas HD-MAPs were applied by both a trained user and self-administered with application sites compared to determine the response of skin and the level of engagement of the HD-MAP with human skin. Twenty healthy participants were enrolled, and the response of skin including erythema was observed at all application sites and no difference was found between trained user or self-administered applications. The majority of participants (70%) preferred the deltoid upper arm application site for applying HD-MAPs. Fluorescent dermatoscope images confirmed HD-MAPs engaged the skin surface and scanning electron microscopy (SEM) image analysis exhibite

SUBMITTER: Baker B 

PROVIDER: S-EPMC10064923 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature