Biomechanical induction of mild brain trauma in larval zebrafish: effects on visual startle reflex habituation.

ABSTRACT: A mild traumatic brain injury is a neurological disturbance of transient or/and chronic nature after a direct blow of the head/neck or exposure of the body to impulsive biomechanical forces, indirectly affecting the brain. The neuropathological events leading to the clinical signs, symptoms and functional disturbances are still elusive due to a lack of sensitive brain-screening tools. Animal models offer the potential to study neural pathomechanisms in close detail. We recently proposed a non-invasive protocol for inducing concussion-like symptoms in larval zebrafish via exposure to rapid linearly accelerating-decelerating body motion. By mean of auditory 'startle reflex habituation' assessments-an established neurophysiological health index-we probed acute and chronic effects that mirror

SUBMITTER: Beppi C 

PROVIDER: S-EPMC10065185 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature