Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women.

ABSTRACT:

Introduction

Metalloproteinases-3 (MMP3) are the main enzymes involved in cartilage degradation. Several genetic and non-genetic factors can increase the expression of MMP3 in patients with osteoarthritis (OA). This study aims to analyze the risk factors associated with the expression of the MMP3 gene rs679620 fluid synovial knee OA patients.

Methods

A cross-sectional study was conducted at the orthopedic polyclinic Arifin Achmad Riau Province and Ibn Sina Hospital in Pekanbaru City. Ninety women who experienced knee OA were taken as samples by consecutive sampling and then signed the informed consent. Data were obtained through interviews using a questionnaire about characteristics, followed by weight and height measurements. Interleukin-1 β (IL-1β) and Tumor Necrosis Facto

SUBMITTER: Sulastri D 

PROVIDER: S-EPMC10065264 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature