Apoplexy in sporadic pituitary adenomas: a single referral center experience and AIP mutation analysis.

ABSTRACT:

Objective

To analyze the clinical, laboratory, and radiological findings and management of patients with clinical pituitary apoplexy and to screen for aryl hydrocarbon receptor-interacting protein (AIP) mutations.

Methods

The clinical findings were collected from the medical records of consecutive sporadic pituitary adenoma patients with clinical apoplexy. Possible precipitating factors, laboratory data, magnetic resonance imaging (MRI) findings and treatment were also analyzed. Peripheral blood samples were obtained for DNA extraction from leukocytes, and the entire AIP coding region was sequenced.

Results

Thirty-five patients with pituitary adenoma were included, and 23 (67%) had non-functioning pituitary adenomas. Headache was observed in 31 (89%) pat

SUBMITTER: Fialho C 

PROVIDER: S-EPMC10065329 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature