Adipose tissue-derived stromal/stem cells + cholecalciferol: a pilot study in recent-onset type 1 diabetes patients.

ABSTRACT:

Objective

Adipose tissue-derived stromal/stem cells (ASCs) and vitamin D have immunomodulatory actions that could be useful for type 1 diabetes (T1D). We aimed in this study to investigate the safety and efficacy of ASCs + daily cholecalciferol (VIT D) for 6 months in patients with recent-onset T1D.

Methods

In this prospective, dual-center, open trial, patients with recent onset T1D received one dose of allogenic ASC (1 × 10⁶ cells/kg) and cholecalciferol 2,000 UI/day for 6 months (group 1). They were compared to patients who received chol-ecalciferol (group 2) and standard treatment (group 3). Adverse events were recorded; C-peptide (CP), insulin dose and HbA1c were measured at baseline (T0), after 3 (T3) and 6 months (T6).

Results

In group 1 (n = 7), adve

SUBMITTER: Dantas JR 

PROVIDER: S-EPMC10065343 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature