Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population.

ABSTRACT:

Objective

To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults.

Methods

This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMA_IR, leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression.

Results

The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase i

SUBMITTER: Mardones L 

PROVIDER: S-EPMC10065347 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature