Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.

ABSTRACT:

Objective

Multiple genetic variants have been studied for years to try to find an association with polycystic ovary syndrome (PCOS). This meta-analysis will investigate if there are associations between increased risk of PCOS and rs6165 polymorphism in follicle stimulating hormone receptor (FSHR) gene and rs2479106 polymorphism in differentially expressed in Differentially Expressed in Normal and Neoplastic Development Isoform 1A (DENND1A) gene.

Methods

Studies were identified from PubMed library, and case-control studies with correct polymorphisms and available genotype frequencies were included. The statistical analysis is done in Review Manager 5.3, and odds ratio (OR) with corresponding 95% confidence interval (CI) was calculated to see if any association with PCOS exist

SUBMITTER: Larsen CB 

PROVIDER: S-EPMC10065767 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature