Effects of clinical, comorbid, and social determinants of health on brain ageing in people with and without HIV: a retrospective case-control study.

ABSTRACT:

Background

Neuroimaging reveals structural brain changes linked with HIV infection and related neurocognitive disorders; however, group-level comparisons between people with HIV and people without HIV do not account for within-group heterogeneity. The aim of this study was to quantify the effects of comorbidities such as cardiovascular disease and adverse social determinants of health on brain ageing in people with HIV and people without HIV.

Methods

In this retrospective case-control study, people with HIV from Washington University in St Louis, MO, USA, and people without HIV identified through community organisations or the Research Participant Registry were clinically characterised and underwent 3-Tesla T₁-weighted MRI between Dec 3, 2008, and Oct 4, 2022. Exc

SUBMITTER: Petersen KJ 

PROVIDER: S-EPMC10065928 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature