Caveolin-3 and Caveolae regulate ventricular repolarization.

ABSTRACT:

Rationale

Flask-shaped invaginations of the cardiomyocyte sarcolemma called caveolae require the structural protein caveolin-3 (Cav-3) and host a variety of ion channels, transporters, and signaling molecules. Reduced Cav-3 expression has been reported in models of heart failure, and variants in CAV3 have been associated with the inherited long-QT arrhythmia syndrome. Yet, it remains unclear whether alterations in Cav-3 levels alone are sufficient to drive aberrant repolarization and increased arrhythmia risk.

Objective

To determine the impact of cardiac-specific Cav-3 ablation on the electrophysiological properties of the adult mouse heart.

Methods and results

Cardiac-specific, inducible Cav3 homozygous knockout (Cav-3KO) mice demonstrated a marked reduction in Cav-3

SUBMITTER: Markandeya YS 

PROVIDER: S-EPMC10065933 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature