Vaccinomics: A scoping review.

ABSTRACT:

Background

This scoping review summarizes a key aspect of vaccinomics by collating known associations between heterogeneity in human genetics and vaccine immunogenicity and safety.

Methods

We searched PubMed for articles in English using terms covering vaccines routinely recommended to the general US population, their effects, and genetics/genomics. Included studies were controlled and demonstrated statistically significant associations with vaccine immunogenicity or safety. Studies of Pandemrix®, an influenza vaccine previously used in Europe, were also included, due to its widely publicized genetically mediated association with narcolepsy.

Findings

Of the 2,300 articles manually screened, 214 were included for data extraction. Six included articles examined genetic

SUBMITTER: Dudley MZ 

PROVIDER: S-EPMC10065969 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature