The potential role of the KFG and KITLG proteins in preventing granulosa cell apoptosis in Bubalus bubalis.

ABSTRACT:

Background

The dynamics of mammalian follicular development and atresia is an intricate process involving the cell-cell communication mediated by secreted ovarian factors. These interactions are critical for oocyte development and regulation of follicular atresia which in part are mediated by keratinocyte growth factor (KGF) and kit ligand (KITLG), but their roles in the regulation of apoptosis in buffalo granulosa cells have not yet been defined. During mammalian follicular development, granulosa cell apoptosis triggers the atresia so ~ 1% follicles reach the ovulation stage. In the present study, we used buffalo granulosa cells to examine the effects of KGF and KITLG in apoptosis regulation and investigated potential mechanism on Fas-FasL and Bcl-2 signaling pathways.

Result</

SUBMITTER: Panwar D 

PROVIDER: S-EPMC10066048 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature