Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer.

ABSTRACT: Adjuvant chemotherapy has played a major role in the treatment of hormone receptor-positive breast cancer for many years. To better determine which patient subsets need adjuvant chemotherapy, various gene expression analyses have been developed, but cost-effective tools to identify such patients remain elusive. In the present report, we retrospectively investigated immunohistochemical expression and subcellular localization of MUC1 in primary tumors and examined their relationship to tumor malignancy, chemotherapy effect and patient outcomes. We retrospectively examined three patient cohorts with hormone receptor-positive/human epidermal growth factor receptor 2-negative invasive breast cancer: 51 patients who underwent 21-gene expression analysis (multi-gene assay-cohort), 96 patients who

SUBMITTER: Semba R 

PROVIDER: S-EPMC10066179 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature