Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis.

ABSTRACT: Multiple psychiatric disorders are characterized by a failure to suppress default-mode network (DMN) activity during tasks and by weaker anti-correlations between DMN and other brain networks at rest. However, the cellular and molecular mechanisms underlying this phenomenon are poorly understood. At the cellular level, neuronal activity is regulated by multiple neurochemical processes including cycling of glutamate and GABA, the major excitatory and inhibitory neurotransmitters in brain. By combining functional MRI and magnetic resonance spectroscopy techniques, it has been shown that the neurotransmitter concentrations in DMN modulate not only functional activity during cognitive tasks, but also the functional connectivity between DMN and other brain networks such as frontoparietal execut

SUBMITTER: Chen X 

PROVIDER: S-EPMC10066209 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature