Capturing effects of blood flow on the transplanted decellularized nephron with intravital microscopy.

ABSTRACT: Organ decellularization creates cell-free, collagen-based extracellular matrices that can be used as scaffolds for tissue engineering applications. This technique has recently gained much attention, yet adequate scaffold repopulation and implantation remain a challenge. Specifically, there still needs to be a greater understanding of scaffold responses post-transplantation and ways we can improve scaffold durability to withstand the in vivo environment. Recent studies have outlined vascular events that limit organ decellularization/recellularization scaffold viability for long-term transplantation. However, these insights have relied on in vitro/in vivo approaches that need enhanced spatial and temporal resolutions to investigate such issues at the microvascular level. This study uses intr

SUBMITTER: Corridon PR 

PROVIDER: S-EPMC10066218 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature