Intoxicating effects of alcohol depend on acid-sensing ion channels.

ABSTRACT: Persons at risk for developing alcohol use disorder (AUD) differ in their sensitivity to acute alcohol intoxication. Alcohol effects are complex and thought to depend on multiple mechanisms. Here, we explored whether acid-sensing ion channels (ASICs) might play a role. We tested ASIC function in transfected CHO cells and amygdala principal neurons, and found alcohol potentiated currents mediated by ASIC1A homomeric channels, but not ASIC1A/2 A heteromeric channels. Supporting a role for ASIC1A in the intoxicating effects of alcohol in vivo, we observed marked alcohol-induced changes on local field potentials in basolateral amygdala, which differed significantly in Asic1a^-/- mice, particularly in the gamma, delta, and theta frequency ranges. Altered electrophysiological responses

SUBMITTER: Harmata GIS 

PROVIDER: S-EPMC10066229 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature