Signatures of T cell immunity revealed using sequence similarity with TCRDivER algorithm.

ABSTRACT: Changes in the T cell receptor (TCR) repertoires have become important markers for monitoring disease or therapy progression. With the rise of immunotherapy usage in cancer, infectious and autoimmune disease, accurate assessment and comparison of the "state" of the TCR repertoire has become paramount. One important driver of change within the repertoire is T cell proliferation following immunisation. A way of monitoring this is by investigating large clones of individual T cells believed to bind epitopes connected to the disease. However, as a single target can be bound by many different TCRs, monitoring individual clones cannot fully account for T cell cross-reactivity. Moreover, T cells responding to the same target often exhibit higher sequence similarity, which highlights the importanc

SUBMITTER: Vujovic M 

PROVIDER: S-EPMC10066310 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature