Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC10066334 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Xu Yaru Y Zhang Huasheng H Wu Shuai S Liu Jianyue J Liu Hongzhi H Wang Dongdi D Zhang Youqin Y Niu Hongshen H Su Xiaohui X Sun Jiping J Shen Lei L
Cellular & molecular immunology 20230125 4
Group 3 innate lymphoid cells (ILC3s) play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation. The transcription factor PLZF (promyelocytic leukemia zinc finger), encoded by zinc finger BTB domain containing 16 (Zbtb16), is highly and transiently expressed in ILC precursors (ILCPs). However, the role of PLZF in regulating ILC3 development and function remains unknown. Here, we show that PLZF was specifically expressed in ...[more]