Disrupted subcortical functional connectome gradient in drug-naive first-episode schizophrenia and the normalization effects after antipsychotic treatment.

ABSTRACT: Antipsychotics are thought to improve schizophrenia symptoms through the antagonism of dopamine D2 receptors, which are abundant mainly in subcortical regions. By introducing functional gradient, a novel approach to identify hierarchy alterations by capturing the similarity of whole brain fucntional connectivity (FC) profiles between two voxels, the present study aimed to characterize how the subcortical gradient is associated with treatment effects and response in first-episode schizophrenia in vivo. Two independent samples of first-episode schizophrenia (FES) patients with matched healthy controls (HC) were obtained: the discovery dataset included 71 patients (FES_0W) and 64 HC at baseline, and patients were re-scanned after either 6 weeks (FES_6W, N = 33) or 12 month

SUBMITTER: Yang C 

PROVIDER: S-EPMC10066388 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature