Optimization of screening strategies for colorectal cancer based on fecal DNA and occult blood testing.

ABSTRACT:

Background

Fecal DNA and occult blood testing have been gradually developed for colorectal cancer (CRC) screening. Comparison of different testing strategies for these methods in CRC screening is in urgent need. This study aims to examine the efficacy of different testing strategies including multi-target fecal DNA testing, qualitative and quantitative fecal immunoassay tests (FITs).

Methods

Fecal samples were collected from patients diagnosed by colonoscopy. Tests using fecal DNA, quantitative FIT or qualitative FIT were performed on same fecal samples. Efficiency of different testing strategies within different populations was investigated.

Results

For high-risk populations (CRC and advanced adenoma), the positive rate of the three methods alone was 74.3-80%; the po

SUBMITTER: Yao T 

PROVIDER: S-EPMC10066493 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature