Alterations in hepatic transcriptome and cecum microbiota underlying potential ways to prevent early fatty liver in laying hens.

ABSTRACT: Fatty liver syndrome (FLS) is a kind of nutritional metabolic disease in laying hens. Revealing FLS pathogenesis during the early period is what really makes sense for the prevention or nutritional regulation strategies. In the study, 9 healthy or naturally occurring early FLS birds were screened based on visual inspection, liver index and morphologic analysis. Liver and fresh cecal content samples were collected. Then transcriptomic and 16S rRNA technologies are applied to investigate hepatic transcriptome and cecum microbiota composition. Unpaired Student t test and some omics methods were used for statistical analysis. Results showed higher liver weight and index were found in FLS group; morphologic analysis indicated that there existed more lipid droplets in the liver of birds with FLS

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10066560 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature