Default mode network failure and neurodegeneration across aging and amnestic and dysexecutive Alzheimer's disease.

ABSTRACT: From a complex systems perspective, clinical syndromes emerging from neurodegenerative diseases are thought to result from multiscale interactions between aggregates of misfolded proteins and the disequilibrium of large-scale networks coordinating functional operations underpinning cognitive phenomena. Across all syndromic presentations of Alzheimer's disease, age-related disruption of the default mode network is accelerated by amyloid deposition. Conversely, syndromic variability may reflect selective neurodegeneration of modular networks supporting specific cognitive abilities. In this study, we leveraged the breadth of the Human Connectome Project-Aging cohort of non-demented individuals (N = 724) as a normative cohort to assess the robustness of a biomarker of default mode netwo

SUBMITTER: Corriveau-Lecavalier N 

PROVIDER: S-EPMC10066575 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature