ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery.

ABSTRACT: It is generally believed that environmental or cutaneous bacteria are the main origin of surgical infections. Therefore, measures to prevent postoperative infections focus on optimizing hygiene and improving asepsis and antisepsis. In a large cohort of patients with infections following major surgery, we identified that the causative bacteria are mainly of intestinal origin. Postoperative infections of intestinal origin were also found in mice undergoing partial hepatectomy. CCR6⁺ group 3 innate lymphoid cells (ILC3s) limited systemic bacterial spread. Such bulwark function against host invasion required the production of interleukin-22 (IL-22), which controlled the expression of antimicrobial peptides in hepatocytes, thereby limiting bacterial spread. Using genetic loss-of-func

SUBMITTER: Jakob MO 

PROVIDER: S-EPMC10066576 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature