A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner.

ABSTRACT: The specification of synaptic properties is fundamental for the function of neuronal circuits. "Terminal selector" transcription factors coordinate terminal gene batteries that specify cell-type-specific properties. Moreover, pan-neuronal splicing regulators have been implicated in directing neuronal differentiation. However, the cellular logic of how splicing regulators instruct specific synaptic properties remains poorly understood. Here, we combine genome-wide mapping of mRNA targets and cell-type-specific loss-of-function studies to uncover the contribution of the RNA-binding protein SLM2 to hippocampal synapse specification. Focusing on pyramidal cells and somatostatin (SST)-positive GABAergic interneurons, we find that SLM2 preferentially binds and regulates alternative splicing of t

SUBMITTER: Traunmuller L 

PROVIDER: S-EPMC10066595 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature