Treatments and outcomes in high-risk gestational trophoblastic neoplasia: A systematic review and meta-analysis.

ABSTRACT:

Background

High-risk gestational trophoblastic neoplasia (GTN) is rare and treated with diverse approaches. Limited published institutional data has yet to be systematically reviewed.

Objectives

To compile global high-risk GTN (prognostic score ≥7) cohorts to summarise treatments and outcomes by disease characteristics and primary chemotherapy.

Search strategy

MEDLINE, Embase, Scopus, ClinicalTrials.gov and Cochrane were searched through March 2021.

Selection criteria

Full-text manuscripts reporting mortality among ≥10 high-risk GTN patients.

Data collection and analysis

Binomial proportions were summed, and random-effects meta-analyses performed.

Main results

From 1137 records, we included 35 studies, representing 20 countries. Among 2276 unique

SUBMITTER: Albright BB 

PROVIDER: S-EPMC10066712 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature