Growth differentiation factor 15 and cardiovascular risk: individual patient meta-analysis.

ABSTRACT:

Aims

Levels of growth differentiation factor 15 (GDF-15), a cytokine secreted in response to cellular stress and inflammation, have been associated with multiple types of cardiovascular (CV) events. However, its comparative prognostic performance across different presentations of atherosclerotic cardiovascular disease (ASCVD) remains unknown.

Methods and results

An individual patient meta-analysis was performed using data pooled from eight trials including 53 486 patients. Baseline GDF-15 concentration was analyzed as a continuous variable and using established cutpoints (<1200 ng/L, 1200-1800 ng/L, > 1800 ng/L) to evaluate its prognostic performance for CV death/hospitalization for heart failure (HHF), major adverse cardiovascular events (MACE), and their components using C

SUBMITTER: Kato ET 

PROVIDER: S-EPMC10066747 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature