A New Index of Insulin Sensitivity from Glucose Sensor and Insulin Pump Data: In Silico and In Vivo Validation in Youths with Type 1 Diabetes.

ABSTRACT: Background: Estimation of insulin sensitivity (S_I) and its daily variation are key for optimizing insulin therapy in patients with type 1 diabetes (T1D). We recently developed a method for S_I estimation from continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) data in adults with T1D (S_I^SP) and validated it under restrained experimental conditions. Herein, we validate in vivo a new version of S_I^SP performing well in daily life unrestrained conditions. Methods: The new S_I^SP was tested in both simulated and real data. The simulated dataset consists of 100 virtual adults of the UVa/Padova T1D Simulator monitored during an open-loop experiment,

SUBMITTER: Schiavon M 

PROVIDER: S-EPMC10066780 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature