In Silico Analysis and Immune Response of YaeT Protein Against Riemerella anatipestifer in Ducks.

ABSTRACT: Riemerella anatipestifer (RA) is one of the most harmful bacterial pathogens in waterfowl and causes enormous economic loss worldwide. Due to weak cross-immunity protection against different serotypes of RA, inactivated and attenuated vaccines are only effective for RA of specific serotypes. In this paper, outer membrane protein YaeT in RA was analyzed through bioinformatics, in vivo, and in vitro assays. Homology, physicochemical and structural properties, transmembrane domains, and B-cell binding epitopes were investigated. The recombinant outer membrane protein YaeT was then inoculated into Cherry Valley ducks to analyze its immune protection against RA. Results showed that the protein was conservative in different RA strains and had sufficient B-cell binding epitopes. The immunized duc

SUBMITTER: Guan Q 

PROVIDER: S-EPMC10066975 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature