Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis.

ABSTRACT: Neutrophils, the most abundant innate immune cells, function as crucial regulators of the adaptive immune system in diverse pathological conditions, including metastatic cancer. However, it remains largely unknown whether their immunomodulatory functions are intrinsic or acquired within the pathological tissue environment. Here, using mouse models of metastatic breast cancer in the lungs, we show that, although neutrophils isolated from bone marrow (BM) or blood are minimally immunosuppressive, lung-infiltrating neutrophils are robustly suppressive of both T cells and natural killer (NK) cells. We found that this tissue-specific immunosuppressive capacity of neutrophils exists in the steady state and is reinforced by tumor-associated inflammation. Acquisition of potent immunosuppression ac

SUBMITTER: Gong Z 

PROVIDER: S-EPMC10067025 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature