Serum glycomic profile as a predictive biomarker of recurrence in patients with differentiated thyroid cancer.

ABSTRACT:

Purpose

Thyroid cancer recurrence following curative thyroidectomy is associated with increased morbidity and mortality, but current surveillance strategies are inadequate for early detection. Prior studies indicate that tissue glycosylation is altered in thyroid cancer, but the utility of serum glycosylation in thyroid cancer surveillance remains unexplored. We therefore assessed the potential utility of altered serum glycomic profile as a tumor-specific target for disease surveillance in recurrent thyroid cancer.

Experimental design

We employed banked serum samples from patients with recurrent thyroid cancer post thyroidectomy and healthy controls. N-glycans were enzymatically released from serum glycoproteins, labeled via permethylation, and analyzed by MALDI-TOF mass spe

SUBMITTER: Kudelka MR 

PROVIDER: S-EPMC10067050 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature