Cancer-testis gene STK31 is regulated by methylation and promotes the development of pancreatic cancer.

ABSTRACT:

Backgroud

Pancreatic cancer (PC) is a highly invasive malignancy with extremely poor prognosis. STK31 has been identified as a cancer-testis (CT) gene, but its function in PC has not been elucidated well.

Methods

The effect of STK31 on cell proliferation, migration and invasion was investigated by in vitro and in vivo experiments and total RNA sequencing and targeted bisulfite sequencing was applied to explore the potential regulatory mechanisms of STK31 in PC.

Results

By analysis of tissue samples and the clinicopathologic features, we found that STK31 was reactivated in PC and associated with poor prognosis. In addition, the vitro and vivo studies indicated that STK31 could promote PC progression by facilitating cell proliferation, migration and invasion, and the in

SUBMITTER: Gao H 

PROVIDER: S-EPMC10067059 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature