High expression of caspase-8 as a predictive factor of poor prognosis in patients with esophageal cancer.

ABSTRACT:

Background

Esophageal carcinoma (ESCA) is considered to be one of the most common gastrointestinal cancers. Caspase-8 (CASP8) is a key protein of cross-talk signaling in a variety of cancers. However, the role of CASP8 expression in the prognosis of patients with ESCA has remained unexplored. Hence, it is needed to explore the clinical significance of CASP8 expression in ESCA.

Methods

The expression and prognosis of CASP8 were investigated in ESCA using the UALCAN, GEDS, TIMER, and OncoLnc databases. The CASP8 genetic variations in ESCA were assessed using the cBioPortal database. The correlation between CASP8 expression and tumor immune invasion and immune cell surface indicators was examined using the TIMER and TISIDTISIDB datasets. Meanwhile, the abundance of the immunolo

SUBMITTER: Chai J 

PROVIDER: S-EPMC10067063 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature