On target methods to induce abscopal phenomenon for Off-Target effects: From happenstance to happenings.

ABSTRACT: Although the "abscopal phenomenon" has been described several decades ago, this phenomenon lately has been obtaining momentous traction with the dawn of immune-based therapies. There has been increased cross talk among radiation oncologists, oncologists and immunologists and consequently a surge in the number of prospective clinical trials. This must be coupled with translation work from these clinical trials to aid in eventual identification of patients who may benefit. Abscopal effects may be induced by local and systemic methods, conventional radiotherapy, particle radiation, radionucleotide methods, cryoablation and brachytherapy. These approaches have all been reported to be stimulate abscopal effect. Immune induction by immune checkpoint therapy, immune adjuvants, cellular therapy in

SUBMITTER: Nelson BE 

PROVIDER: S-EPMC10067075 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature