Genomic alterations and clinical outcomes in patients with dedifferentiated liposarcoma.

ABSTRACT:

Purpose

Patients with unresectable dedifferentiated liposarcoma (DDLPS) have poor overall outcomes. Few genomic alterations have been identified with limited therapeutic options.

Experimental design

Patients treated at Levine Cancer Institute with DDLPS were identified. Next generation sequencing (NGS), immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH) testing were performed on tumor tissue collected at diagnosis or recurrence/progression. Confirmation of genomic alterations was performed by orthologous methods and correlated with clinical outcomes. Univariate Cox regression was used to identify genomic alterations associated with clinical outcomes.

Results

Thirty-eight DDLPS patients with adequate tissue for genomic profiling and clinical data

SUBMITTER: Jagosky MH 

PROVIDER: S-EPMC10067084 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature