Screening of potential microbial markers for lung cancer using metagenomic sequencing.

ABSTRACT:

Introduction

Lung cancer is the most prevalent cancer with high mortality in China, and it is associated with the dysbiosis of the lung microbiome. This study attempted to screen for specific microorganisms as potential biomarkers for distinguishing benign lung disease from lung cancer.

Methods

Bronchoalveolar lavage fluid (BALF) sample was selected in the study instead of saliva to avoid contamination with oral microorganisms, and microbial taxonomic and functional differences in BALF samples from patients with lung cancer and those with those from patients with benign lung diseases were performed based on metagenomic next-generation sequencing, for the first time, so that microorganisms other than bacteria could be included.

Results

The results showed that the intra

SUBMITTER: Chen Q 

PROVIDER: S-EPMC10067086 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature