Causal associations between gastroesophageal reflux disease and lung cancer risk: A Mendelian randomization study.

ABSTRACT:

Background

Observational epidemiological studies suggest that lung cancer risk may be raised by gastroesophageal reflux disease (GERD); however, the causal relationship between them remains unknown. Our study performed the two-sample Mendelian randomization (MR) approach to examine the causal relationship between GERD and lung cancer.

Methods

Instrument variables were found to be independent single nucleotide polymorphisms (SNPs) that were highly linked with GERD (n = 129,080). Summary data from genome-wide association studies (GWAS) data were used to determine outcomes for lung cancer (n = 11,348), squamous cell lung cancer (LUSC), and lung adenocarcinoma (LUAD). In this study, three MR statistical techniques (inverse variance weighted (IVW), MR-Egger, and weighted median)

SUBMITTER: Li L 

PROVIDER: S-EPMC10067102 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature