ABO blood groups and expression of blood group antigens of epithelial ovarian cancer in Chinese women.

ABSTRACT:

Background

ABO blood groups has been associated with risk of several cancers; however, the results for an association with ovarian cancer are inconsistent and little is known about the expression of histo-blood group (ABH) antigens and ABO gene in ovarian tumor tissues.

Methods

To assess the impact of genotype-derived ABO blood types on the risk of EOC, we conducted a case-control study in 1,870 EOC and 4,829 controls. Expression of A and B antigen in 70 pairs of ovarian tumor tissues and adjacent normal tissues were detected by immunohistochemistry. Gene expression and DNA methylation profiling was conducted in ovarian tumor tissues.

Results

We identified that blood group A was associated with increased risk for EOC compared to blood group O (OR = 1.18, 95% CI = 1.03

SUBMITTER: Wang C 

PROVIDER: S-EPMC10067109 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature