Dendritic cell vaccines improve the glioma microenvironment: Influence, challenges, and future directions.

ABSTRACT:

Introduction

Gliomas, especially the glioblastomas, are one of the most aggressive intracranial tumors with poor prognosis. This might be explained by the heterogeneity of tumor cells and the inhibitory immunological microenvironment. Dendritic cells (DCs), as the most potent in vivo functional antigen-presenting cells, link innate immunity with adaptive immunity. However, their function is suppressed in gliomas. Therefore, overcoming the dysfunction of DCs in the TME might be critical to treat gliomas.

Method

In this paper we proposed the specificity of the glioma microenvironment, analyzed the pathways leading to the dysfunction of DCs in tumor microenvironment of patients with glioma, summarized influence of DC-based immunotherapy on the tumor microenvironment and propose

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10067114 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature