Hsa-circ-0052001 promotes gastric cancer cell proliferation and invasion via the MAPK pathway.

ABSTRACT:

Background

Gastric cancer (GC) ranks fourth among the causes of death from malignant tumors in the world. Studies have implicated the dysregulation of circRNAs with GC. However, the relationship between hsa-circ-0052001 and GC is unclear.

Methods

In our current study, we assessed the expression levels of hsa-circ-0052001 in GC cells and tissues using quantitative real-time PCR (qPCR). The role of hsa-circ-0052001 expression on the proliferation and invasion of GC cells was assessed using in vitro experiments. The role of hsa-circ-0052001 on the proliferation of GC cells was also analyzed using in vivo models. The pathways downstream of hsa-circ-0052001 were identified using bioinformatics analyses, western blot (WB) assays, and qRT-PCR.

Results

We found that compared

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10067131 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature